tag:blogger.com,1999:blog-2706107744577821742026-03-09T09:57:10.444+00:00The Blog Site for DNAReplication.netSue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.comBlogger2244125tag:blogger.com,1999:blog-270610774457782174.post-19365761372008190762026-03-09T09:57:00.001+00:002026-03-09T09:57:10.429+00:00<b>MCM10, a novel YAP1/TEAD4 target, drives gastric cancer progression by bridging DNA replication to stemness acquisition </b> Fuda Xie, Hoi Wing Leung, Yang Lyu, Peiyao Yu, Tiejun Feng, Bonan Chen, Jialin Wu, Jenson Tham, Canbin Fang, Alvin H.K. Cheung, Chit Chow, Jianhui Jiang, Jintao Hu, Fengbin Zhang, Chaowei Zhu, Keli Zhong, Meiheng Sun, Ge Zhang, Sifan Yu, Dazhi Xu, Shouyu Wang, Bing Huang, Kangmin Zhuang, Xiaobei Luo, Aimin Li, Qing Guo, Chanchan Gao, Bin Zhang, Yuan Ma, William KK Wu, Liwei An, Chi Chun Wong, Jun Yu, Ka Fai To & Wei Kang <a href="https://link.springer.com/article/10.1186/s12943-026-02623-8?utm_source=bmc_etoc&amp;utm_medium=email&amp;utm_campaign=CONR_12943_AWA1_GL_DTEC_054CI_TOC-260301">Molecular cancer </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-88183057804788218922026-03-09T09:56:00.000+00:002026-03-09T09:56:00.172+00:00<b>Molecular impacts of Meier–Gorlin syndrome mutations on human origin licensing</b> Ran Yang ∙ Olivia Hunker ∙ Jenna Kim ∙ Franziska Bleicher <a href="https://www.jbc.org/article/S0021-9258%2825%2902952-7/fulltext?dgcid=raven_jbs_etoc_email%20">Journal of Biological Chemistry, Volume 302, Issue 2, 111100 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-29742499160859040582026-03-09T09:55:00.001+00:002026-03-09T09:55:10.993+00:00<b>Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cells </b> Elisa Balzano∙ Shyam Twayana ∙ Settapong T. Kosiyatrakul ∙ Glennis A. Logsdon ∙ Bhushan L. Thakur ∙ Evan E. Eichler ∙ Bettina Bohl ∙ Philipp Koch ∙ Simone Sidoli ∙ Anupama Kumari ∙ Katherine M. Munson ∙ Kendra Hoekzema ∙ Mirit I. Aladjem ∙ Carl L. Schildkraut <a href="https://www.cell.com/iscience/fulltext/S2589-0042%2826%2900082-9%20">iScience, Volume 29, Issue 2, 114707 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-11598393528277350132026-03-09T09:54:00.002+00:002026-03-09T09:54:18.667+00:00<b>A Meier–Gorlin syndrome mutation impairs the loading of the MCM2–7 complex during DNA replication initiation </b> Yusong Liu , Mengquan Yang , Ping Lu, +8 , and Hongtao Yu <a href="https://www.pnas.org/doi/abs/10.1073/pnas.2526022123?af=R">PNAS February 20, 2026 123 (8) e2526022123 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-36125554495950254512026-03-09T09:53:00.002+00:002026-03-09T09:53:15.750+00:00<b>A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis</b> Gabriella N.L. Chua ∙ Emily C. Beckwitt ∙ Victoria Miller-Browne ∙ Olga Yuriev ∙ Dan Zhang ∙ Bryce J. Katch ∙ Nina Y. Yao ∙ John W. Watters ∙ Kaitlin Abrantes ∙ Ryogo Funabiki ∙ Xiaolan ZhaoMichael E. O’Donnell ∙ Shixin Liu <a href="https://www.cell.com/cell/fulltext/S0092-8674%2825%2901478-3?dgcid=raven_jbs_etoc_email%20">Cell volume 189, Issue 4P1124-1134.E14February 19, 2026 </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-71977246804042694162026-03-09T09:52:00.002+00:002026-03-09T09:52:16.161+00:00<b>Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability</b> Carlos Origel Marmolejo ∙ Celina Sanchez ∙ Erin Helms ∙ Melissa J. McEvoy ∙ Juyoung Lee ∙ Marcel Werner ∙ Paige Robert’s ∙ Stephan Hamperl ∙ Joshua C. Saldivar <a href="https://www.cell.com/molecular-cell/fulltext/S1097-2765%2826%2900025-0?dgcid=raven_jbs_etoc_email%20">Mol cell Volume 86, Issue 4P640-655.E6February 19, 2026 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-12600320364198617372026-03-09T09:51:00.003+00:002026-03-09T09:51:23.633+00:00<b>ADAR1 is an editor of DNA replication forks. </b> Petryk, N. <a href="https://doi.org/10.1038/s41594-025-01737-9%20">Nat Struct Mol Biol 33, 198–199 (2026). </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-45859108687600293362026-03-09T09:50:00.001+00:002026-03-09T09:50:17.505+00:00<b>Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity</b> Bin Chen, Guangchao Sun, Jake A. Kloeber, Huaping Xiao, Yaobin Ouyang, Fei Zhao, Ya Li, Shilin Xu, Sonja Dragojevic, Zheming Wu, Shouhai Zhu, Yiqun Han, Ping Yin, Xinyi Tu, Hongran Qin, Xiang Zhou, Kuntian Luo, Kevin L. Peterson, Jinzhou Huang, Taro Hitosugi, Haiming Dai, Min Deng, Robert W. Mutter & Zhenkun Lou  <a href="https://www.nature.com/articles/s41594-025-01736-w?utm_source=nature_etoc&amp;utm_medium=email&amp;utm_campaign=CONR_41594_AWA1_GL_DTEC_054CI_TOC-260219&amp;utm_content=20260219.">Nature Structural & Molecular Biology volume 33, pages 293–303 (2026) </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-45135353445382884842026-03-09T09:48:00.006+00:002026-03-09T09:48:37.369+00:00<b>FANCD2 restrains fork progression and prevents fragility at early origins upon re-replication</b> Nibal Badra-Fajardo, Elena Karydi, Aleix Bayona-Feliu, Belén Gómez-González, Ourania Preza, Marina Arbi, Argyro Kalogeropoulou, Juha K. Rantala, Stavros Taraviras, Andrés Aguilera & Zoi Lygerou  <a href="https://www.nature.com/articles/s41467-026-68966-4%20">Nature Communications , </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-51153670029867678222026-03-09T09:47:00.006+00:002026-03-09T09:47:46.932+00:00<b>DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains</b> Yui Imaizumi, François Charon, Caroline Surcis, Christel Picard, Pol Arnau-Romero, Jean-Christophe Andrau, Daan Noordermeer, Benoit Moindrot, Jean-Charles Cadoret & Robert Feil  Nature Communications ,(2026) <a href="https://www.nature.com/articles/s41467-026-68558-2."></a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-41898488739090876342026-03-09T09:46:00.746+00:002026-03-09T09:46:53.985+00:00<b>Automated mapping of DNA replication fork progression in human cells with ForkML</b> Victoria Rojat, Diletta Ciardo, Alan Tourancheau, Florence Proux, Etienne Jean, Jean- Michel Arbona, Benjamin Audit, Gael A. Millot, Frédéric Bonhomme, Paola B. Arimondo, Olivier Hyrien & Benoît Le Talle <a href="https://doi.org/10.1038/s41467-026-68750-4%20">Nat Commun (2026).</a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-23206825766614601752026-03-09T09:45:00.008+00:002026-03-09T09:45:55.368+00:00<b>PAF15–PCNA exhaustion governs the strand-specific control of DNA replication</b> Gita Chhetri, Sugith Babu Badugu, Narcis-Adrian Petriman, Mikkel Bo Petersen, Aylin Seren Güller, Nora Fajri, Manon Coulée, Ganesha Pandian Pitchai, Jan Novotný, Frederik Tibert Larsen, Andreas Fønss Møller, Morten Frendø Ebbesen, Tina Ravnsborg, Anoop Kumar Yadav, Barath Balarasa, Anita Lunding, Hana Polasek-Sedlackova, Ole N. Jensen, Kim Ravnskjaer, Jonathan R. Brewer, Jesper Grud Skat Madsen, Nataliya Petryk, Jens S. Andersen & Kumar Somyajit <a href="https://doi.org/10.1038/s41586-025-10011-3">Nature (2026). </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-2117843861940471982026-03-09T09:44:00.006+00:002026-03-09T09:44:39.298+00:00<b>Evidence for a functional interaction between yeast Pol ε and PCNA in vivo </b> Noopur Singh , Roni Odai , Ulf Persson , Göran O Bylund , Ikenna Obi , Nasim Sabouri , Gemma C Atkinson , Erik Johansson <a href="https://doi.org/10.1093/nar/gkaf1339.%20">Nucleic Acids Research, Volume 53, Issue 22, 11 December 2025, gkaf1339, </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-87415785233219367922026-03-09T09:43:00.006+00:002026-03-09T09:43:43.196+00:00<b>OCT4 enhances the firing efficiency of late DNA replication origins in mouse embryonic stem cells</b> Eddie Rodriguez-Carballo, Vasilis S. Dionellis, Sotirios G. Ntallis, Lilia Bernasconi, Ezgi G. Keskin & Thanos D. Halazonetis  <a href="https://www.nature.com/articles/s41467-026-68389-1">Nature Communications , </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-46234444501583908632026-03-09T09:42:00.006+00:002026-03-09T09:42:39.453+00:00<b>AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms. </b> Hunker, O., Bleichert, F. <a href="https://doi.org/10.1038/s44318-025-00628-5">EMBO J 45, 310–333 (2026). </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-80260446266589372822026-03-09T09:41:00.001+00:002026-03-09T09:41:15.610+00:00<b>Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes </b> Dario D’Asaro, Jean-Michel Arbona, Vinciane Piveteau, Aurèle Piazza, Cédric Vaillant & Daniel Jost <a href="https://link.springer.com/article/10.1186/s13059-025-03872-4?utm_source=bmc_etoc&amp;utm_medium=email&amp;utm_campaign=CONR_13059_AWA1_GL_DTEC_054CI_TOC-260101%20">Genome Biology Volume 26, article number 431, (2025) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-32525508758720018462025-12-24T09:44:00.001+00:002025-12-24T09:44:08.001+00:00<b>Assembly of a homohexameric minichromosome maintenance complex is dependent on ATP and DNA </b> Oliver W. Noble ∙ Clement Degut∙ Michael R. Hodgkinson ∙ James P.J. Chong ∙ Michael J. Plevin <a href="about:invalid#zSoyz">Journal of Biological Chemistry, </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-53652026659068799792025-12-24T09:43:00.003+00:002025-12-24T09:43:22.808+00:00<b>Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes </b> Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki <a href="https://doi.org/10.1002/1873-3468.70193.%20">Volume599, Issue24 December 2025 Pages 3669-3684 </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-12183776632805755552025-12-24T09:38:00.006+00:002025-12-24T09:38:40.125+00:00<b>The non-catalytic DNA polymerase ε subunit is an NPF motif recognition protein </b> Salla Keskitalo, Boglarka Zambo, Dicle Malaymar Pinar, Antti Tuhkala, Kari Salokas, Tanja Turunen, Norbert Deutsch, Norman Davey, Zsuzsanna Dosztányi, Markku Varjosalo & Gergo Gogl  <a href="about:invalid#zSoyz">Nature Communications , </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-4831293672713523412025-12-24T09:37:12.221+00:002025-12-24T09:37:53.355+00:00<b>License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication </b> Victoria Frisbie, Franziska Bleichert <a href="https://doi.org/10.1002/bies.70095%20%20">Bio essays. Volume48, Issue1 January 2026 e70095 </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-89422508837418961382025-12-24T09:37:00.002+00:002025-12-24T09:37:09.928+00:00<b>Emerging roles of RNA:DNA hybrid regulation by mammalian ribonuclease H2 in replication stress and cancer </b> Rosanna Wilkins, Eva Petermann <a href="https://doi.org/10.1242/jcs.264148%20">J Cell Sci (2025) 138 (23): jcs264148. </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-47515288087208490042025-12-24T09:35:00.006+00:002025-12-24T09:35:30.739+00:00<b>Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions </b> Joshua Tomkins, Lucy V. Edwardes, Sarah V. Faull, Matthew Peach, Peter J. Gillespie, Vera Leber, Anna Schmidt, Halil Bounoua, Nicholas Sim, Rosa Camarillo, J. Julian Blow, Alexis R. Barr, Anna Barnard& Christian Speck  <a href="https://doi.org/10.1038/s41467-025-67073-0.%20">Nat Commun (2025). </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-89579638602555172532025-12-24T09:34:00.005+00:002025-12-24T09:34:36.216+00:00<b>Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication </b> Xiaoxuan Zhu, Atabek Bektash, Yuki Hatoyama, Sachiko Muramatsu, Shin-Ya Isobe, Chikashi Obuse, Atsushi Toyoda, Yasukazu Daigaku, Chun-Long Chen & Masato T. Kanemaki  <a href="https://www.nature.com/articles/s41467-025-66278-7%20">Nature Communications volume 16, Article number: 10069 (2025) </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-82534690518610081322025-12-24T09:33:11.783+00:002025-12-24T09:33:56.216+00:00<b>Spatial mapping of DNA synthesis reveals dynamics and geometry of human replication nanostructures </b> Michael Hawgood Bruno Urién Ana Agostinho Praghadhesh Thiagarajan Giovanni Giglio, Yiqiu Yang Xue Zhang Gemma Quijada Matilde Fonseca Jiri Bartek1 Hans Blom & Bennie Lemmens <a href="https://doi.org/10.1038/s44318-025-00574-2%20">EMBO J 44, 7263–7294 (2025). </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-66747085091797918592025-12-24T09:33:00.000+00:002025-12-24T09:33:08.357+00:00<b>The A, B, C, D’s of replicative DNA polymerase fidelity: utilizing high-throughput single-molecule sequencing to understand the molecular basis for DNA polymerase accuracy </b> Leonardo Betancurt-Anzola , Killian C O’Connell , Vladimir Potapov , Jennifer L Ong , Nathan A Tanner , Ludovic Sauguet , Kelly M Zatopek <a href="https://doi.org/10.1093/nar/gkaf1143.%20">Nucleic Acids Research, Volume 53, Issue 21, 26 November 2025, gkaf1143, </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0