tag:blogger.com,1999:blog-2706107744577821742026-07-20T17:00:31.847+01:00The Blog Site for DNAReplication.netSue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.comBlogger2278125tag:blogger.com,1999:blog-270610774457782174.post-33726580478403586852026-07-20T17:00:31.847+01:002026-07-20T17:00:31.847+01:00<b>A TRIM28–MCM7 regulatory axis sustains DNA replication programs in glioblastoma</b> Xiaosong Hu, Li Yang, Hongjuan Cui <a href="https://www.sciencedirect.com/science/article/pii/S0006291X26009149"> Biochemical and Biophysical Research Communications Volume 829, 3 September 2026, 154150 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-42379262638393770802026-07-20T16:59:42.942+01:002026-07-20T16:59:42.943+01:00<b>Structural and mechanistic insights into primer synthesis initiation by DNA primase</b> Pengzhi Wu, Fred F. Damberger, Johannes Zehnder, Nina Wehr, Niklas Senning, Georg Lipps, Thomas Wiegand & Frédéric H.-T. Allain <a href="https://www.nature.com/articles/s41467-026-74862-8%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-10220182630495733092026-07-20T16:58:48.364+01:002026-07-20T16:58:48.364+01:00<b>CHD1L maintains genome integrity by facilitating okazaki fragment maturation</b> Litong Nie , Jialing Fu , Min Huang , Huimin Zhang , Tiantian Ma , Chang Yang , Siting Li , Chao Wang , Junjie Chen <a href="about:invalid#zSoyz">Nucleic Acids Research, Volume 54, Issue 12, 8 July 2026, gkag606,</a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-51424031844935486992026-07-20T16:58:03.005+01:002026-07-20T16:58:03.005+01:00<b>DNA-damage dependent interaction of Orc6 to SMARCA1 in S-phase modulates chromatin remodeling </b> Dazhen Liu , Mohit Mishra , Youyang Wang , Humayra Oishi , Aneek Mirza , Iman Fatimah Mohajir , Neha Chetlangia , Jay Sonalkar , Yo-Chuen Lin , Kannanganattu V Prasanth and Supriya G Prasanth <a href="https://doi.org/10.1093/nar/gkag582%20">Nucleic Acids Research, Volume 54, Issue 12, 8 July 2026, gkag582, </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-83176423740817284852026-07-20T16:57:01.907+01:002026-07-20T16:57:01.908+01:00<b>RECQ4 arginine methylation suppresses single-stranded DNA gap accumulation at replication forks</b> Ning Ma , Xiaohua Xu , Michael Espinoza , Chou-Wei Chang , Yukari Shiozaki , Zhigang Guo , Louis Izuagie , Binghui Shen , Yanzhong Yang , Yilun Liu <a href="about:invalid#zSoyz">Nucleic Acids Research, Volume 54, Issue 12, 8 July 2026, gkag655,</a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-25130919865412619172026-07-20T16:56:14.153+01:002026-07-20T16:56:14.153+01:00<b>Replication origin firing capacity indicates ATR inhibitor sensitivity</b> A. Lumeau, P. L. Pfuderer, J. A. Scarth, E. Maniati, M. A. Guscott, N. Shaikh, F. B. Copley, H. Gerdes, S. De Angelis, E. L. Alard, J. Wang, P. R. Cutillas, F. K. Mardakheh, M. A. Boemo, J. V. Forment & S. E. McClelland <a href="https://www.nature.com/articles/s41467-026-74588-7%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-26371934015863065072026-07-20T16:55:22.320+01:002026-07-20T16:55:22.320+01:00<b>Spatial organization and dynamics of genome replication: from forks to foci </b> Sunil K Pradhan , Maria Arroyo , Maruthi K Pabba , Heinrich Leonhardt , M Cristina Cardoso <a href="https://doi.org/10.1093/nar/gkag550%20">Nucleic Acids Research, Volume 54, Issue 11, 24 June 2026, gkag550, </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-54303027996628207092026-07-20T16:54:14.767+01:002026-07-20T16:54:14.768+01:00<b>Distinct repair outcomes from single and convergent replication fork collapse</b> Sara C. Conwell, Khushi V. N. Patel, Savannah J. Weeks-Pollenz, Steven N. Dahmen, Matthew T. Cranford, William G. Dunphy, David T. Long, David Cortez & James M. Dewar <a href="https://www.nature.com/articles/s41594-026-01812-9?utm_source=nature_etoc&amp;utm_medium=email&amp;utm_campaign=CONR_41594_AWA1_GL_DTEC_054CI_TOC-260618&amp;utm_content=20260618">Nature Structural & Molecular Biology volume 33, pages 939–952 (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-2654847383388693302026-07-20T16:53:29.309+01:002026-07-20T16:53:29.309+01:00<b>Structure of the pre-initiation complex explains CMGE biogenesis</b> Thomas Pühringer, Berta Canal, Giacomo Palm, Agata Butryn, Emma C. Couves, Oliver Willhoft, Jacob S. Lewis, John F. X. Diffley & Alessandro Costa <a href="https://www.nature.com/articles/s41586-026-10657-7?WT.ec_id=NATURE-202606">Nature (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-14191408630444983182026-07-20T16:52:40.580+01:002026-07-20T16:52:40.580+01:00<b>TASP1-mediated cleavage of REV3L enhances the activity of DNA polymerase ζ in mammalian cells</b> Jordane Goulas, Basile Guignier, Barbara Ben Yamin, Caroline Pouvelle, Andrey Yurchenko, Emmanuelle Despras, Luciana de Oliveira, Pierre Laplante, Dorian Bochaton, Damien Plassard, Wei Yang, François-Xavier Theillet, Xavier Veaute, Richard D. Wood, Sergey Nikolaev, Agnès M. Cordonnier & Patricia L. Kannouche  <a href="https://www.nature.com/articles/s41467-026-74271-x%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-44042978562302975252026-07-20T16:51:42.529+01:002026-07-20T16:51:42.530+01:00<b>ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity</b> Richard R. Spinks, Aleksa Lakic, Celine Kelso, Slobodan Jergic, Olga Yurieva, Zhi-Qiang Xu, Michael E. O’Donnell, Nicholas E. Dixon, Antoine M. van Oijen, Jacob S. Lewis & Lisanne M. Spenkelink  <a href="https://doi.org/10.1038/s41467-026-73893-5">Nat Commun (2026). </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-1042803597825227012026-07-20T16:50:51.838+01:002026-07-20T16:50:51.839+01:00<b>Replication origin flexibility: a tool to mitigate the hazards of excess replication</b> Haiqing Fu ∙ Christophe E. Redon ∙ Hannah M. Brenner ∙ Michael R. Ack ∙ Mirit I. Aladjem <a href="https://www.cell.com/trends/genetics/fulltext/S0168-9525%2826%2900057-0?dgcid=raven_jbs_etoc_email">Trends in Genetics, 2026; 42, 510-523 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-73164904894172800742026-07-20T16:50:00.110+01:002026-07-20T16:50:00.111+01:00<b>Primase subunit 2 regulates the proliferation and apoptosis of gastric cancer cells via MCM7/CDK4 and Bax/Bcl-2 pathways</b> Biochimica et Biophysica Acta (BBA) - General Subjects <a href="https://www.sciencedirect.com/science/article/pii/S0304416526000474">Volume 1870, Issue 7, July 2026, 130947 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-87455292705809172712026-07-20T16:49:12.619+01:002026-07-20T16:49:12.619+01:00<b>Regulation of DNA replication and 3D genome organization during early embryogenesis</b> Ichiro Hiratani <a href="https://www.sciencedirect.com/science/article/pii/S0959437X26000365">Current Opinion in Genetics & Development June 2026 Article: 102469 Volume: Volume 98 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-83676768247384254202026-07-20T16:48:19.383+01:002026-07-20T16:48:19.383+01:00<b>An updated view on lagging strand DNA replication: implications for the replication stress response</b> Rodrigo Martín-Rufo & Emilio Lecona <a href="https://doi.org/10.1080/15384101.2026.2646889">Cell cycle 25 Pages 1-16 22 Mar 2026 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-68320590347184345612026-07-20T16:47:23.776+01:002026-07-20T16:47:23.776+01:00<b>Deciphering the dual effects of transcription on DNA replication elongation by replication-associated Micro-C</b> Zhengrong Zhangding ∙ Xuhao Liu ∙ Haoxin Liang ∙ Yaxu Fan ∙ Yu Peng ∙ Wanqin Rao ∙ Wanlin Chen ∙ Jiazhi Hu <a href="https://www.cell.com/molecular-cell/fulltext/S1097-2765%2826%2900210-8?dgcid=raven_jbs_etoc_email%20">Molecular Cell, 2026; 86, 1870-1880.e5 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-57559061897514217932026-07-20T16:46:17.287+01:002026-07-20T16:46:17.287+01:00<b>Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR</b> Jung-Hoon Yoon, Karthi Sellamuthu, Robert E. Johnson, Louise Prakash and Satya Prakash <a href="https://genesdev.cshlp.org/content/early/2026/05/13/gad.353474.125.abstract?papetoc">Genes & Dev. 2026. </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-7496466758533555492026-07-20T16:45:21.526+01:002026-07-20T16:45:21.526+01:00<b>Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection</b> Jeffrey N. Katz, Lorena Samentar, Qingming Fang, Jae-Hoon Ji, Wenjing Li, Qiongmei Gao, Sahiti Kuppa, Boya Gao, Cody M. Rogers, Hardeep Kaur, Aida Badamchi Shabestari, Arijit Dutta, Shahrez Syed, Miriam Tovar, Nozomi Tomimatsu, Bipasha Mukherjee, Elizabeth M. Irvin, Shuo Zhou, Amyn A. Habib, David S. Libich, Robert Hromas, Alexander V. Mazin, Manjeet K. Rao, Shaun K. Olsen, Elizabeth V. Wasmuth, Ana Losada, Daohong Zhou, Hong Wang, Li Lan, Eric C. Greene, Weixing Zhao, Youngho Kwon, Sandeep Burma & Patrick Sung  <a href="https://www.nature.com/articles/s41467-026-73479-1%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-19823169370656799752026-07-20T16:44:28.429+01:002026-07-20T16:44:28.429+01:00<b>Dynamic regulation of origin firing factors links CDK activity to dormant origin activation </b> Md Shahadat Hossain, Courtney G. Sansam, Kimberlie A. Wittig, Tyler D. Noble, Kevin A. Boyd & Christopher L. Sansam  <a href="https://www.nature.com/articles/s41467-026-73333-4%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-49854766783910809582026-07-20T16:43:36.440+01:002026-07-20T16:43:36.440+01:00<b>Visualization of the complete preprimosome reveals the structural mechanisms governing DNA replication restart </b> Peter L. Ducos, Alexander T. Duckworth, Kenneth A. Satyshur, James L. Keck & Timothy Grant <a href="https://www.nature.com/articles/s41467-026-73239-1%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-48237736791619673812026-07-20T16:42:42.294+01:002026-07-20T16:42:42.294+01:00<b>Distinct roles of MCM2-7 subunits in replication licensing in human cells</b> Xinyu Fan, Wai Hei Lam, Daqi Yu, Huadong Jiang, Yan Chit Hui, Qiongdan Zhang, Weiran Li, Jian Li, Ziyang Lin, Zhan Yin, Wenxiong Wu, Yingyi Zhang, Nan Liu, Masato T. Kanemaki, Shangyu Dang & Yuanliang Zhai  <a href="https://www.nature.com/articles/s41467-026-73118-9%20">Nature Communications </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-50412743807757958252026-07-20T16:41:52.637+01:002026-07-20T16:41:52.637+01:00<b>Topological stress regulates replication fork dynamics in unperturbed S phase</b> Deepika Jayaprakash, Josie Gannon Patterson, Ruthie Mulvaney, Quinn Dickinson, Courtney Lovejoy, Mads Lerdrup, Juan Carlos Rivera-Mulia, David Cortez & Rahul Bhowmick  <a href="https://www.nature.com/articles/s41467-026-73330-7%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-29337729785563365412026-07-20T16:40:54.107+01:002026-07-20T16:40:54.107+01:00<b>ATM lifts the cGAS handbrake on DNA replication.</b> Lin, YL., Pasero, P. <a href="https://doi.org/10.1038/s41556-026-01944-6%20">Nat Cell Biol 28, 842–843 (2026). </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-25184593183434861182026-07-20T16:39:56.433+01:002026-07-20T16:39:56.433+01:00<b>ATM counteracts chromatin-bound cGAS during DNA replication</b> Yunhao Song, Xiaojuan Ran, Yu Xu, Kartik Subramanian, Chao Dai, Mavrakis Konstantinos, Li Lan, Vipin Yadav & Lee Zou  <a href="https://www.nature.com/articles/s41556-026-01931-x?utm_source=nature_etoc&amp;utm_medium=email&amp;utm_campaign=CONR_41556_AWA1_GL_DTEC_054CI_TOC-260516&amp;utm_content=20260516">Nature Cell Biology volume 28, pages 946–956 (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-49139281535037847462026-07-20T16:39:02.155+01:002026-07-20T16:39:02.155+01:00<b>Proximal proteomics analysis reveals DNA polymerase δ subunit 3 is a new MCM2 binding partner and promotes parental histones inheritance in mammalian cells</b> Yaping Sun, Xiaoyan Liang, Fang Liu, Wenjuan Zhao, Jiaqi Zhou, Yue Li, Yuan Yao, Ziwei Zhang, Gang Li, Kuiming Chan, Daoqin Zhang, Zhiquan Wang, Yuan Gao, Chuanhe Yu, Yuchun Wu, Xing Kang, Lingyu Qiu, Nan Li & Haiyun Gan <a href="https://www.nature.com/articles/s41418-025-01619-z?utm_source=nature_etoc&amp;utm_medium=email&amp;utm_campaign=CONR_41418_AWA1_GL_DTEC_054CI_TOC-260509&amp;utm_content=20260509">Cell Death & Differentiation volume  33, pages 1050–1064 (2026) </a>Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0