Welcome to the Interactive Section of the site. Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here.

Clamping Pol ε to the leading strand

31-Dec-2024 18:34 | Permalink
Noopur Singh & Erik Johansson Nature Structural & Molecular Biology volume 31, pages 1644–1645 (2024)
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In vivo DNA replication dynamics unveil aging-dependent replication stress

31-Dec-2024 18:33 | Permalink
Giacomo G. Rossetti, Noe ̈ lle Dommann, Angeliki Karamichali, Vasilis S. Dionellis, Ainhoa Asensio Aldave, Tural Yarahmadov, Eddie Rodriguez-Carballo, Adrian Keogh, Daniel Candinas, Deborah Stroka and Thanos D. Halazonetis Cell 187,6220–6234 2024
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Four decades of Eukaryotic DNA replication: From yeast genetics to high-resolution cryo-EM structures of the replisome

31-Dec-2024 18:31 | Permalink
Bik-Kwoon Tye PNAS 121 (42) e2415231121 2024
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Assembly and activation of replicative helicases at origin DNA for replication initiation

31-Dec-2024 18:30 | Permalink
Qiongdan Zhang, Wai Hei Lam, Yuanliang Zhai Current Opinion in Structural BiologyVolume 88 102876 2024
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A common mechanism for recruiting the Rrm3 and RTEL1 accessory helicases to the eukaryotic replisome

31-Dec-2024 18:28 | Permalink
Ottavia Olson, Simone Pelliciari, Emma D Heron, and Tom D Deegan EMBO J 43: 3846 - 3875 (2024)
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Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex

31-Dec-2024 18:27 | Permalink
Yue Wu, Qiongdan Zhang, Yuhan Lin, Wai Hei Lam & Yuanliang Zhai Nature Communications volume 15, Article number: 8039 (2024)
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USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication

31-Dec-2024 18:24 | Permalink
Hannah L. Mackay, Helen R. Stone, George E. Ronson, Katherine Ellis, Alexander Lanz, Yara Aghabi, Alexandra K. Walker, Katarzyna Starowicz, Alexander J. Garvin, Patrick Van Eijk, Stefan A. Koestler, Elizabeth J. Anthony, Ann Liza Piberger, Anoop S. Chauhan, Poppy Conway-Thomas, Alina Vaitsiankova, Sobana Vijayendran, James F. Beesley, Eva Petermann, Eric J. Brown, Ruth M. Densham, Simon H. Reed, Felix Dobbs, Marco Saponaro & Joanna R. Morris Nature Communications volume 15, Article number: 8102 (2024)
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Timely lagging strand maturation relies on Ubp10 deubiquitylase-mediated PCNA dissociation from replicating chromatin

31-Dec-2024 18:24 | Permalink
Javier Zamarreño, Sofía Muñoz, Esmeralda Alonso-Rodríguez, Macarena Alcalá, Sergio Rodríguez, Rodrigo Bermejo, María P. Sacristán & Avelino Bueno Nature Communications volume 15, Article number: 8183 (2024)
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Structures of the human leading strand Polε–PCNA holoenzyme

31-Dec-2024 18:23 | Permalink
Qing He, Feng Wang, Nina Y. Yao, Michael E. O’Donnell & Huilin Li Nature Communications volume 15, Article number: 7847 (2024)
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Pioneer factors for DNA replication initiation in metazoans

31-Dec-2024 18:22 | Permalink
Yue Wang, Jing Liang Volume46,2400002 2024
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MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing

31-Dec-2024 18:20 | Permalink
L. Maximilian Reuter, Sanjay P. Khadayate, Audrey Mossler, Korbinian Liebl, Sarah V. Faull, Mohammad M. Karimi & Christian Speck Nature Communications volume 15, Article number: 7306 (2024)
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Single-molecule characterization of SV40 replisome and novel factors: human FPC and Mcm10

31-Dec-2024 18:20 | Permalink
Yujing Ouyang, Amani Al-Amodi, Muhammad Tehseen, Lubna Alhudhali, Afnan Shirbini, Masateru Takahashi, Vlad-Stefan Raducanu, Gang Yi, Ammar Usman Danazumi, Alfredo De Biasio, Samir M Hamdan Nucleic Acids Research, Volume 52 Pages 8880–8896 2024
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Embryonic genome instability upon DNA replication timing program emergence

31-Dec-2024 18:19 | Permalink
Saori Takahashi, Hirohisa Kyogoku, Takuya Hayakawa, Hisashi Miura, Asami Oji, Yoshiko Kondo, Shin-ichiro Takebayashi, Tomoya S. Kitajima & Ichiro Hiratani Nature volume 633, pages 686–694 (2024)
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A high-throughput screening identifies MCM chromatin loading inhibitors targeting cells with increased replication origins

31-Dec-2024 18:18 | Permalink
Lucia Falbo, Herve ́ Te ́ cher, Vincenzo Sannino, Michela Robusto, Giovanni Faga, Federica Pezzimenti, Francesco Romeo, Luca Gabriele Colombo, Stefania Vultaggio, Daniele Fancelli, Silvia Monzani, Valentina Cecatiello, Sebastiano Pasqualato, Mario Varasi, Ciro Mercurio and Vincenzo Costanzo iScience 27, 110567 2024
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How Mcm10 converts the pre-replication complex into two diverging DNA forks

31-Dec-2024 18:16 | Permalink
Nature Structural & Molecular Biology volume 31, pages 1150–1151 (2024)
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Unwinding of a eukaryotic origin of replication visualized by cryo-EM

31-Dec-2024 18:15 | Permalink
Sarah S. Henrikus, Marta H. Gross, Oliver Willhoft, Thomas Pühringer, Jacob S. Lewis, Allison W. McClure, Julia F. Greiwe, Giacomo Palm, Andrea Nans, John F. X. Diffley & Alessandro Costa Nature Structural & Molecular Biology volume 31, pages 1265–1276 (2024)
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SUMO protease and proteasome recruitment at the nuclear periphery differently affect replication dynamics at arrested forks

31-Dec-2024 18:14 | Permalink
Kamila Schirmeisen, Karel Naiman, Karine Fréon, Laetitia Besse, Shrena Chakraborty, Anissia Ait Saada, Antony M Carr, Karol Kramarz, Sarah A E Lambert Nucleic Acids Research, Volume 52 Pages 8286–8302 2024
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Origin recognition complex 6 overexpression promotes growth of glioma cells

31-Dec-2024 18:13 | Permalink
Wen-lei Yang, Wei-feng Zhang, Yin Wang, Yue Lou, Yu Cai & Jun Zhu Cell Death & Disease volume 15, Article number: 485 (2024)
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Sex-specific DNA-replication in the early mammalian embryo

31-Dec-2024 18:12 | Permalink
Jason Alexander Halliwell, Javier Martin-Gonzalez, Adnan Hashim, John Arne Dahl, Eva R. Hoffmann & Mads Lerdrup Nature Communications volume 15, Article number: 6323 (2024)
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Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa

31-Dec-2024 18:08 | Permalink
Riki Terui1∙ Scott E. Berger∙ Larissa A. Sambel1∙ Dan Song∙ Gheorghe Chistol Cell Volume 187, Issue 15P3992-4009, 2024
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DNA polymerase κ participates in early S-phase DNA replication in human cells

31-Dec-2024 18:06 | Permalink
Feng Tang, Yinan Wang, Ting Zhao, Jun Yuan, Andrew H. Kellum Jr, and Yinsheng Wang PNAS 121 (28) e2405473121 2024
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Activity of DNA polymerase κ across the genome in human fibroblasts

31-Dec-2024 18:03 | Permalink
Mariela C. Torres, Abbey Rebok, Dongxiao Sun, and Thomas E. Spratt https:// PNAS 121 (28) e2403130121 2024
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Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution

31-Dec-2024 18:01 | Permalink
Michelle Dietzen, Haoran Zhai, Olivia Lucas, Oriol Pich, Christopher Barrington, Wei-Ting Lu, Sophia Ward, Yanping Guo, Robert E. Hynds, Simone Zaccaria, Charles Swanton, Nicholas McGranahan & Nnennaya Kanu Nature Communications volume 15, Article number: 6039 (2024)
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Control of DNA replication in vitro using a reversible replication barrier

31-Dec-2024 18:01 | Permalink
Emma J. Vontalge, Tamar Kavlashvili, Steven N. Dahmen, Matthew T. Cranford & James M. Dewar Nature Protocols volume 19, pages 1940–1983 (2024)
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MCM8 interacts with DDX5 to promote R-loop resolution

31-Dec-2024 18:00 | Permalink
Canxin Wen, Lili Cao, Shuhan Wang, Weiwei Xu, Yongze Yu, Simin Zhao, Fan Yang, Zi-Jiang Chen, Shidou Zhao, Yajuan Yang, and Yingying Qin EMBO J 43: 3044 - 3071 (2024)
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Quantifying DNA replication speeds in single cells by scEdU-seq

31-Dec-2024 17:58 | Permalink
Jeroen van den Berg, Vincent van Batenburg, Christoph Geisenberger, Rinskje B. Tjeerdsma Anchel de Jaime-Soguero, Sergio P. Acebrón, Marcel A. T. M. van Vugt & Alexander van Oudenaarden Nature Methods | Volume 21 1175–1184 2024
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The loss of DNA polymerase epsilon accessory subunits POLE3–POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

31-Dec-2024 17:55 | Permalink
Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, Eva Pinto Jurado, Siham Zentout, Alexandra Mihuţ, Anna Georgina Kopasz, Mihály Mérey, Rebecca Smith, Abhishek Bharadwaj Sharma, Nicholas D Lakin, Andrew James Bowman, Lajos Haracska, Sébastien Huet, Gyula Timinszky Nucleic Acids Research, Volume 52 Pages 6994–7011 2024
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Mapping fast DNA polymerase exchange during replication

31-Dec-2024 17:53 | Permalink
Longfu Xu, Matthew T. J. Halma & Gijs J. L. Wuite Nature Communications volume 15, Article number: 5328 (2024)
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DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility

31-Dec-2024 17:53 | Permalink
Shuangyi Xu, Ning Wang, Michael V. Zuccaro, Jeannine Gerhardt, Rajan Iyyappan, Giovanna Nascimento Scatolin, Zongliang Jiang, Timour Baslan, Amnon Koren & Dieter Egli Nature Communications volume 15, Article number: 5247 (2024)
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Phosphorylation of Orc6 During Mitosis Regulates DNA Replication and Ribosome Biogenesis

31-Dec-2024 17:52 | Permalink
Fredy Kurniawana , Arindam Chakraborty, Humayra Z. Oishi, Minxue Liu, Mariam K. Arif, David Chen, Molecular and Cellular Biology Volume 44 Pages 289-301 2024
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Replication protein A dynamically re-organizes on primer/template junctions to permit DNA polymerase δ holoenzyme assembly and initiation of DNA synthesis

31-Dec-2024 17:50 | Permalink
Jessica L Norris, Lindsey O Rogers, Kara G Pytko, Rachel L Dannenberg, Samuel Perreault, Vikas Kaushik, Sahiti Kuppa, Edwin Antony, Mark Hedglin Nucleic Acids Research, Volume 52 Pages 7650–7664 2024
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CryoEM insights into RNA primer synthesis by the human primosome

31-Dec-2024 17:47 | Permalink
Zhan Yin, Mairi L. Kilkenny, De-Sheng Ker, Luca Pellegrini Febs J Volume291 Pages 1813-1829 2024
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Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors

31-Dec-2024 17:45 | Permalink
Bethany Rebekah Hill, Meryem Ozgencil, Lauryn Buckley-Benbow, Sophie Louise Pamela Skingsley, Danielle Tomlinson, Carmen Ortueta Eizmendi, Alessandro Agnarelli,and Roberto Bellelli Cell Reports 43, 114205, 2024
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Improved detection of DNA replication fork-associated proteins

31-Dec-2024 17:43 | Permalink
Rebecca S. Rivard,Ya-Chu Chang, Ryan L. Ragland, Yee-Mon Thu, Muzaffer Kassab, Rahul Shubhra Mandal, Susan K. Van Riper, Katarzyna Kulej, LeeAnn Higgins, Todd M. Markowski, David Shang, Jack Hedberg, Luke Erber, Benjamin Garcia, Yue Chen, Anja-Katrin Bielinsky and Eric J. Brown Cell Reports 43, 114178 2024
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S-phase checkpoint prevents leading strand degradation from strand-associated nicks at stalled replication forks

31-Dec-2024 17:40 | Permalink
Alberto Bugallo, Mar Sánchez, María Fernández-García, Mónica Segurado Nucleic Acids Research, Volume 52 Pages 5121–5137 2024
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DNA polymerase delta governs parental histone transfer to DNA replication lagging strand

31-Dec-2024 17:39 | Permalink
Congcong Tian, Qin Zhang, Jing Jia, +18 , and Haiyun Gan PNAS 121 (20) e2400610121 2024
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The origin recognition complex requires chromatin tethering by a hypervariable intrinsically disordered region that is functionally conserved from sponge to man

31-Dec-2024 17:38 | Permalink
Olubu A Adiji, Brendan S McConnell, Matthew W Parker Nucleic Acids Research, Volume 52 Pages 4344–4360 2024
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Mechanism of DNA unwinding by MCM8-9 in complex with HROB

31-Dec-2024 17:37 | Permalink
Ananya Acharya, Hélène Bret, Jen-Wei Huang, Martin Mütze, Martin Göse, Vera Maria Kissling, Ralf Seidel, Alberto Ciccia, Raphaël Guérois & Petr Cejka Nature Communications volume 15, Article number: 3584 (2024)
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Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication

31-Dec-2024 17:36 | Permalink
Jacob T. Landeck ∙ Joshua Pajak ∙ Emily K. Norman ∙ Emma L. Sedivy ∙ Brian A. Kelch JBC Volume 300, Issue 4107166 2024
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A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation

31-Dec-2024 17:34 | Permalink
Patricia Ubieto-Capella, Pilar Ximénez-Embún, Daniel Giménez-Llorente, Ana Losada, Javier Muñoz, Juan Méndez Cell Reports Volume 43, Issue 4114024 2024
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The functional significance of the RPA- and PCNA-dependent recruitment of Pif1 to DNA

31-Dec-2024 16:32 | Permalink
Oleksii Kotenko and Svetlana Makovets EMBO Rep 25: 1734 - 1751(2024)
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The ORFIUS complex regulates ORC2 localization at replication origins

31-Dec-2024 16:31 | Permalink
Zelei Yang, Saie Mogre, Ruiyang He, Emma L Berdan, Shannan J Ho Sui, Sarah J Hill NAR Cancer, Volume 6 zcae003
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Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences

31-Dec-2024 16:30 | Permalink
Michal Chappleboim, Segev Naveh-Tassa, Miri Carmi, Yaakov Levy, Naama Barkai Nucleic Acids Research, Volume 52 Pages 5720–5731 2024
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PrimPol Variant V102A with Altered Primase and Polymerase Activities

31-Dec-2024 16:18 | Permalink
Elizaveta O. Boldinova, Andrey G. Baranovskiy, Yulia V. Filina, Regina R. Miftakhova, Yana F. Shamsutdinova, Tahir H. Tahirov, Alena V. Makarova Journal of Molecular Biology Volume 436 168542 2024
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Parental histone transfer caught at the replication fork

31-Dec-2024 16:16 | Permalink
Ningning Li, Yuan Gao, Yujie Zhang, Daqi Yu, Jianwei Lin, Jianxun Feng, Jian Li, Zhichun Xu, Yingyi Zhang, Shangyu Dang, Keda Zhou, Yang Liu, Xiang David Li, Bik Kwoon Tye, Qing Li, Ning Gao & Yuanliang Zhai Nature volume 627, pages 890–897 (2024)
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RTF2 controls replication repriming and ribonucleotide excision at the replisome

31-Dec-2024 16:15 | Permalink
Brooke A. Conti, Penelope D. Ruiz, Cayla Broton, Nicolas J. Blobel, Molly C. Kottemann, Sunandini Sridhar, Francis P. Lach, Tom F. Wiley, Nanda K. Sasi, Thomas Carroll & Agata Smogorzewska Nature Communications volume 15, Article number: 1943 (2024)
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CST–polymerase α-primase solves a second telomere end-replication problem

31-Dec-2024 16:14 | Permalink
Hiroyuki Takai, Valentina Aria, Pamela Borges, Joseph T. P. Yeeles & Titia de Lange Nature volume 627, pages 664–670 (2024)
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TopBP1 utilises a bipartite GINS binding mode to support genome replication

31-Dec-2024 16:13 | Permalink
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver & Dominik Boos Nature Communications volume 15, Article number: 1797 (2024)
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The Atad5 RFC-like complex is the major unloader of proliferating cell nuclear antigen in Xenopus egg extracts

31-Dec-2024 16:12 | Permalink
Yoshitaka Kawasoe, Sakiko Shimokawa, Peter J. Gillespie, J. Julian Blow, Toshiki Tsurimoto1, Tatsuro S. Takahashi JBC Volume 300, Issue 1105588 2024
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The P286R mutation of DNA polymerase ε activates cancer-cell-intrinsic immunity and suppresses endometrial tumorigenesis via the cGAS-STING pathway

31-Dec-2024 16:10 | Permalink
Ming Tang, Shasha Yin, Hongliang Zeng, Ao Huang, Yujia Huang, Zhiyi Hu, Ab Rauf Shah, Shuyong Zhang, Haisen Li & Guofang Chen Cell Death & Disease volume 15, Article number: 69 (2024)
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The genetic landscape of origins of replication in P. falciparum

31-Dec-2024 16:10 | Permalink
Casilda Muñoz Castellano, Laurent Lacroix, Emilie Mathis, Paulina Prorok, Magali Hennion, Jose-Juan Lopez-Rubio, Marcel Méchali, Ana Rita Gomes Nucleic Acids Research, Volume 52 Pages 660–676 2024
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Coordination of cohesin and DNA replication observed with purified proteins

31-Dec-2024 16:08 | Permalink
asuto Murayama, Shizuko Endo, Yumiko Kurokawa, Ayako Kurita, Sanae Iwasaki & Hiroyuki Araki Nature volume 626, pages 653–660 (2024)
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DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors

31-Dec-2024 16:07 | Permalink
Daria Ostroverkhova,Kathrin Tyryshkin, Annette K. Beach, Elizabeth A. Moore, Yosef Masoudi-Sobhanzadeh, Stephanie R. Barbari, Igor B. Rogozin, Konstantin V. Shaitan, Anna R. Panchenko,and Polina V. Shcherbakova Cell Reports 43, 113655 2024
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Incomplete reprogramming of DNA replication timing in induced pluripotent stem cells

31-Dec-2024 16:05 | Permalink
Matthew M. Edwards, Ning Wang, Dashiell J. Massey, Sakshi Bhatele, Dieter Egli,Amnon Koren Cell reports Volume 43, Issue 1113664 2024
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Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA

31-Dec-2024 16:03 | Permalink
Rebecca Martin , Claudia Y. Espinoza , Christopher R. L. Large, Joshua Rosswork, Cole Van Bruinisse, Aaron W. Miller, Joseph C. Sanchez, Madison Miller, Samantha Paskvan, Gina M. Alvino, Maitreya J. Dunham, M. K. Raghuraman, Bonita J. Brewer PLoS Genet 20(1): e1010850.
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Specialized replication mechanisms maintain genome stability at human centromeres

31-Dec-2024 16:02 | Permalink
Andrea Scelfo,Annapaola Angrisani,Marco Grillo, Jérôme Déjardin, Therese Wilhelm Daniele Fachinetti Mol Cell Volume 84, Issue 6P1003-1020.E10 2024
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The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands

31-Dec-2024 15:55 | Permalink
Tasnim Ahmad, Ryotaro Kawasumi, Tomoya Taniguchi, Takuya Abe, Kazuhiro Terada, Masataka Tsuda, Naoto Shimizu, Toshiki Tsurimoto, Shunichi Takeda, Kouji Hirota Nucleic Acids Research, Volume 51 Pages 12288–12302 2023
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Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency

31-Dec-2024 15:54 | Permalink
Anna Chanou, Matthias Weiβ, Karoline Holler, Atiqa Sajid, Tobias Straub, Jana Krietsch, Andrea Sanchi, Henning Ummethum, Clare S K Lee, Elisabeth Kruse, Manuel Trauner, Marcel Werner, Maxime Lalonde, Massimo Lopes, Antonio Scialdone, Stephan Hamperl Nucleic Acids Research, Volume 51 Pages 12303–12324 2023
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DEK oncoprotein participates in heterochromatin replication via SUMO-dependent nuclear bodies

31-Dec-2024 15:50 | Permalink
Agnieszka Pierzynska-Mach, Christina Czada, Christopher Vogel, Eva Gwosch, Xenia Osswald, Denis Bartoschek, Alberto Diaspro, Ferdinand Kappes, Elisa Ferrando-May J Cell Sci (2023) 136: jcs261329.
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Mechanism of eukaryotic origin unwinding is a dual helicase DNA shearing process

31-Dec-2024 15:49 | Permalink
Lance D. Langston, Roxana E. Georgescu, and Michael E. O'Donnell PNAS 120 e2316466120 2023
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DONSON is required for CMG helicase assembly in the mammalian cell cycle

31-Dec-2024 15:47 | Permalink
Cecile Evrin, Vanesa Alvarez, Johanna Ainsworth, Ryo Fujisawa, Constance Alabert, and Karim Labib EMBO rep 24: e57677 (2023)
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Disorders in the CMG helicase complex increase the proliferative capacity and delay chronological aging of budding yeast

31-Dec-2024 15:45 | Permalink
Karolina Stępień, Adrianna Skoneczna, Monika Kula-Maximenko, Łukasz Jurczyk, Mateusz Mołoń Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchVolume 1871 2024, 119621
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RIF1 regulates early replication timing in murine B cells

31-Dec-2024 15:44 | Permalink
Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N. Klein, Mariia Nazarova, Ursula E. Schoeberl, David M. Gilbert, Sara C. B. Buonomo, Michela Di Virgilio, Tobias Neumann & Rushad Pavri Nature Communications volume 14, Article number: 8049 (2023)
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Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication OriginsR

31-Dec-2024 15:42 | Permalink
Roch Tremblaya, Yosra Mehrjoo, Oumaima Ahmed, Antoine Simoneau, Mary E. McQuaid, El Bachir Affar, Corey Nislow, Guri Giaever & Hugo Wurtele Molecular and Cellular Biology Volume 43 Pages 566-595 2023
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Replication‐induced DNA secondary structures drive fork uncoupling and breakage

31-Dec-2024 15:39 | Permalink
Sophie L Williams, Corella S Casas‐Delucchi, Federica Raguseo, Dilek Guneri, Yunxuan Li, Masashi Minamino, Emma E Fletcher, Joseph TP Yeeles, Ulrich F Keyser, Zoë AE Waller, Marco Di Antonio and Gideon Coster EMBO J 42: e114334(2023)
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The structural mechanism of dimeric DONSON in replicative helicase activation

31-Dec-2024 15:37 | Permalink
Milos A. Cvetkovic1,Paolo Passaretti Agata Butryn Alicja Reynolds-Winczura, Georgia Kingsley, Aggeliki Skagia, Cyntia Fernandez-Cuesta, Divyasree Poovathumkadavil, Roger George, Anoop Chauhan, Satpal Jhujh, Grant S. Stewart, Agnieszka Gambus, and Alessandro Costa Molecular Cell Volume 83 P4017-4031 2023
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A sensor complements the steric gate when DNA polymerase ϵ discriminates ribonucleotides

31-Dec-2024 15:29 | Permalink
Vimal Parkash, Yashraj Kulkarni, Göran O Bylund, Pia Osterman, Shina Caroline Lynn Kamerlin, Erik Johansson Nucleic Acids Research, Volume 51 Pages 11225–11238 2023
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Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism

31-Dec-2024 15:25 | Permalink
Amr M. Al-Zain, Mattie R. Nester, Iffat Ahmed & Lorraine S. Symington Nature Communications volume 14, Article number: 7020 (2023)
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Coordination of Primer Initiation Within the Catalytic Domain of Human PrimPol

31-Dec-2024 15:24 | Permalink
Lewis J. Bainbridge, Katerina Zabrady, Aidan J. Doherty Journal of Molecular Biology Volume 435 168338 2023
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Cooperative interaction of CST and RECQ4 resolves G‐quadruplexes and maintains telomere stability

31-Dec-2024 15:22 | Permalink
Tingfang Li, Miaomiao Zhang, Yanjing Li, Xinyu Han, Lu Tang, Tengfei Ma, Xiaotong Zhao, Rui Zhao, Yuwen Wang, Xue Bai, Kai Zhang, Xin Geng, Lei Sui, Xuyang Feng, Qiang Zhang, Yang Zhao, Yang Liu, Jason A Stewart, and Feng Wang EMBO rep 24: e55494 (2023)
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Distinct RPA functions promote eukaryotic DNA replication initiation and elongation

31-Dec-2024 15:20 | Permalink
Alexandra M Pike, Caitlin M Friend, Stephen P Bell Nucleic Acids Research, Volume 51,Pages 10506–10518 2023
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Flexibility and Distributive Synthesis Regulate RNA Priming and Handoff in Human DNA Polymerase α-Primase

31-Dec-2024 15:19 | Permalink
John J. Cordoba, Elwood A. Mullins, Lauren E. Salay, Brandt F. Eichman, Walter J. Chazin Journal of Molecular Biology Volume 435 168330 2023
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Freedom to err: The expanding cellular functions of translesion DNA polymerases

31-Dec-2024 15:17 | Permalink
Ines Paniagua and Jacqueline J.L. Jacobs Molecular Cell 83 3608 2023
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Review Completing genome replication outside of S phase

31-Dec-2024 15:16 | Permalink
Rahul Bhowmick, Ian D. Hickson, and Ying Liu Molecular Cell 83 3596 2023
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DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation

31-Dec-2024 15:14 | Permalink
Georgia Kingsley, Aggeliki Skagia, Paolo Passaretti, Cyntia Fernandez-Cuesta, Alicja Reynolds-Winczura, Kinga Koscielniak, Agnieszka Gambus Nucleic Acids Research, Volume 51, Pages 9748–9763
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Function and mechanism of MCM8 in the development and progression of colorectal cancer

31-Dec-2024 15:13 | Permalink
Shaojun Yu, Weixing Dai, Senlin Zhao, Yongzhi Yang, Ye Xu, Jianwei Wang, Qun Deng, Jinghu He and Debing Shi Journal of Translational Medicine (2023) 21:623
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Synergism between CMG helicase and leading strand DNA polymerase at replication fork

31-Dec-2024 15:11 | Permalink
Zhichun Xu, Jianrong Feng, Daqi Yu, Yunjing Huo, Xiaohui Ma, Wai Hei Lam, Zheng Liu, Xiang David Li, Toyotaka Ishibashi, Shangyu Dang & Yuanliang Zhai Nature Communications volume 14, Article number: 5849 (2023)
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DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans

31-Dec-2024 15:09 | Permalink
YISUI XIA, REMI SONNEVILLE, MICHAEL JENKYN-BEDFORD, LIQIN JI, CONSTANCE ALABERT, YE HONG, JOSEPH T. P. YEELES, AND KARIM P. M. LABIB SCIENCE Vol 381, Issue 6664
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In silico protein interaction screening uncovers DONSON’s role in replication initiation

31-Dec-2024 15:08 | Permalink
YANG LIM, LUKAS TAMAYO-ORREGO, ERNST SCHMID, ZYGIMANTE TARNAUSKAITE, OLGA V. KOCHENOVA, RHIAN GRUAR, SACHIKO MURAMATSU, LUKE LYNCH, AITANA VERDU SCHLIE,PAULA CARROLL, GEORGHE CHISTOL, MARTIN REIJNS, MASATU KANEMAKI, ANDREW JACKSON, AND JOHANNES C. WALTER SCIENCE Vol 381, Issue 6664
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A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin

31-Dec-2024 14:59 | Permalink
Sumon Sahu, Babatunde E Ekundayo, Ashish Kumar, and Franziska Bleichert EMBO J 42: e114654 (2023)
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Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation

31-Dec-2024 14:52 | Permalink
Yoshitami Hashimoto , Kota Sadano, Nene Miyata, Haruka Ito, and Hirofumi Tanaka EMBO J 42: e114131(2023)
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