Noc3
Suggested to have a role in initiation (1)
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Synonyms |
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Molecular weight |
76 kDa (Sc) |
Biochemical properties |
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Motifs |
•bHLH •NLS |
Protein interactions |
Sc •ORC, Mcm2-7 (1) •Mcm5 (1)
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Modifications |
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Cellular location and expression |
Sc •Binds to ori (ARS) DNA sequence all through the cell cycle
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Other comments |
•DNA replication function only reported in Sc
•Needs ORC for chromatin association
•Previously isolated as tRNA and pre ribosome maturation factor
•Not required in vitro for preRC formation (2).
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Revised by |
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Last edited |
13 Apr 08 |
1. Zhang,Y., Yu,Z., Fu,X. and Liang,C. (2002) Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell 109, 849-860.
2. Kawasaki,Y., Kim,H.D., Kojima,A., Seki,T. and Sugino,A. (2006) Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro. Genes Cells 11, 745-756.