Welcome to the Interactive Section of the site. Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here.

publication alert

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε Vladislav O. Sviderskiy, Lili Blumenberg, Elizabeth Gorodetsky, Sylvia Adams, Kelly V. Ruggles, Richard Possemato Mol Cell VOLUME 80, ISSUE 4, P682-698.E7,
Comments

publication alert

Pif1, RPA, and FEN1 modulate the ability of DNA polymerase δ to overcome protein barriers during DNA synthesis Melanie A. Sparks, Peter M. Burgers* and Roberto Galletto The Journal of Biological Chemistry 295, 15883-15891.
Comments

publication alert

Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy Kouta Mayanagi, Keisuke Oki, Naoyuki Miyazaki, Sonoko Ishino, Takeshi Yamagami, Kosuke Morikawa, Kenji Iwasaki, Daisuke Kohda, Tsuyoshi Shirai & Yoshizumi Ishino BMC Biology volume 18, Article number: 152 (2020)
Comments

publication alert

Equilibrium between nascent and parental MCM proteins protects replicating genomes Hana Sedlackova, Maj-Britt Rask, Rajat Gupta, Chunaram Choudhary, Kumar Somyajit & Jiri Lukas Nature (2020).
Comments

publication alert

Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path Thomas Dodd, Margherita Botto, Fabian Paul, Rafael Fernandez-Leiro , Meindert H. Lamers and Ivaylo Ivanov NATURE COMMUNICATIONS (2020)11:5379
Comments

publication alert

The DNA replication fork suppresses CMG unloading from chromatin before termination Emily Low, Gheorghe Chistol, Manal S. Zaher, Olga V. Kochenova, and Johannes C. Walter GENES & DEVELOPMENT 34:1534–1545
Comments

publication alert

PRIM1 deficiency causes a distinctive primordial dwarfism syndrome David A. Parry,Lukas Tamayo-Orrego, Paula Carroll, Joseph A. Marsh, Philip Greene, Olga Murina, Carolina Uggenti,Andrea Leitch, The Scottish Genomes Partnership, Rita Káposzta, Gabriella Merő, Andrea Nagy, Brigitta Orlik, Balázs Kovács-Pászthy, Alan J. Quigley,Magdolna Riszter, Julia Rankin, Martin A.M. Reijns, Katalin Szakszon, and Andrew P. Jackson GENES & DEVELOPMENT 34:1520–1533
Comments

publication alert

Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication Ikenna Obi, Matilda Rentoft, Vandana Singh, Jan Jamroskovic, Karam Chand, Erik Chorell, Fredrik Westerlund, Nasim Sabouri Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10998–11015,
Comments

publication alert

CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication Haihua Feng, Jingchen Lu, Xiaotian Song, Angkana Thongkum, Fan Zhang, Lihong Lou, Ofer Reizes, Alexandru Almasan, Zihua Gong Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10940–10952,
Comments

publication alert

A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine Matthew T Cranford, Joseph D Kaszubowski, Michael A Trakselis Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10986–10997,
Comments