Welcome to the Interactive Section of the site. Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here.

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Human DNA polymerase α has a strong mutagenic potential at the initial steps of DNA synthesis Alisa E Lisova, Andrey G Baranovskiy, Lucia M Morstadt, Nigar D Babayeva, Tahir H Tahirov Nucleic Acids Research, Volume 50, Issue 21, 28 November 2022, Pages 12266–12273,
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New insights into DNA polymerase mechanisms provided by time-lapse crystallography Tyler M.Weaver, M. Todd Washington, Bret D.Freudenthal Current Opinion in Structural Biology Volume 77, December 2022, 102465
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Pold4 is dispensable for mouse development, DNA replication and DNA repair XuepingGu, Qinjin Dai, PengDu, Ning Li, Jiahui Li, Simiao Zeng, Shuyi Peng, Shengjun Tang, Lei Wang, Zhongcheng Zhou Gene Volume 851, 30 January 2023, 147029
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Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation Martin Meagher, Alexander Myasnikov, and Eric J. Enemark Int. J. Mol. Sci. 2022, 23(23), 14678;
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Global landscape of replicative DNA polymerase usage in the human genome Eri Koyanagi, Yoko Kakimoto, Tamiko Minamisawa, Fumiya Yoshifuji, Toyoaki Natsume, Atsushi Higashitani, Tomoo Ogi, Antony M. Carr, Masato T. Kanemaki & Yasukazu Daigaku Nature Communications volume 13, Article number: 7221 (2022)
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The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells Sameera Vipat, Dipika Gupta, Sagun Jonchhe, Hele Anderspuk, Eli Rothenberg & Tatiana N. Moiseeva Nature Communications volume 13, Article number: 7099 (2022)
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Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions Karl-Uwe Reusswig, Julia Bittmann, Martina Peritore, Mathilde Courtes, Benjamin Pardo, Michael Wierer, Matthias Mann & Boris Pfander Nature Communications volume 13, Article number: 7014 (2022)
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Trypanosoma brucei Mitochondrial DNA Polymerase POLIB Contains a Novel Polymerase Domain Insertion That Confers Dominant Exonuclease Activity Stephanie B. Delzell, Scott W. Nelson, Matthew P. Frost, and Michele M. Klingbeil* Biochemistry 23, 2751–2765 November 18, 2022
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Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics Vlad-Stefan Raducanu, Muhammad Tehseen, Amani Al-Amodi, Luay I. Joudeh, Alfredo De Biasio & Samir M. Hamdan Nature Communications volume 13, Article number: 6973 (2022)
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Cell division drives DNA methylation loss in late-replicating domains in primary human cells Jamie L. Endicott, Paula A. Nolte, Hui Shen & Peter W. Laird Nature Communications volume 13, Article number: 6659 (2022)
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Unexpected new insights into DNA clamp loaders Huilin Li, Mike O'Donnell, Brian Kelch Bioessays Volume44, Issue11 November 2022
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DNA replication timing: Biochemical mechanisms and biological significance Nicholas Rhind Bioassays Volume44, Issue11 November 2022
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Replicon hypothesis revisited Hisao Masai Biochemical and Biophysical Research Communications Volume 633, 10 December 2022, Pages 77-80
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Replicon-seq: seeing is believing Cristian Polo Rivera Tom D. Deegan Trends in Genetics VOLUME 38, ISSUE 10, P987-988,
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Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L Cuige Zhu, Mari Iwase, Ziqian Li, Faliang Wang, Annabel Quinet, Alessandro Vindigni & Jieya Shao Nature Communications volume 13, Article number: 6531 (2022)
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Global early replication disrupts gene expression and chromatin conformation in a single cell cycle Miguel M. Santos, Mark C. Johnson, Lukáš Fiedler & Philip Zegerman Genome Biology volume 23, Article number: 217 (2022)
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Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability Michael B. Heskett, Athanasios E. Vouzas, Leslie G. Smith, Phillip A. Yates, Christopher Boniface, Eric E. Bouhassira, Paul T. Spellman, David M. Gilbert & Mathew J. Thayer Nature Communications volume 13, Article number: 6301 (2022)
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DNA polymerase epsilon binds histone H3.1-H4 and recruits MORC1 to mediate meiotic heterochromatin condensationCong Wang, Jiyue Huang, Yingping Li, Jun Zhang, Chengpeng He, Tianyang Li, Danhua Jiang, Aiwu Dong, Hong Ma, Gregory P. Copenhaver, and Yingxiang Wang PNAS 119 (43) e2213540119
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Origin recognition complex harbors an intrinsic nucleosome remodeling activity Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, and Shixin Liu PNAS 119 (42) e2211568119
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Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes Hana Polasek-Sedlackova, Thomas C. R. Miller, Jana Krejci, Maj-Britt Rask & Jiri Lukas Nature Communications volume 13, Article number: 6090 (2022)
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DNA polymerase epsilon interacts with SUVH2/9 to repress the expression of genes associated with meiotic DSB hotspot in Arabidopsis Cong Wang, Jiyue Huang, Jun Zhang, Yue Yu, Gregory P. Copenhaver, Chenjiang You, and Yingxiang Wang PNAS 119 (41) e2208441119
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Rpd3 regulates single-copy origins independently of the rDNA array by opposing Fkh1-mediated origin stimulation Yiwei He, Meghan V. Petrie, Haiyang Zhang, Jared M. Peace, and Oscar M. Aparicio PNAS 119 (40) e2212134119
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ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress Xingxuan Wu, Shibin Xu, Peipei Wang,Zhao-Qi Wang, Hongxiang Chen, Xingzhi Xu , and Bin Peng PNAS 119 (40) e2203783119
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The consequences of differential origin licensing dynamics in distinct chromatin environments Liu Mei, Katarzyna M Kedziora, Eun-Ah Song, Jeremy E Purvis, Jeanette Gowen Cook Nucleic Acids Research, Volume 50, Issue 17, 23 September 2022, Pages 9601–9620,
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Tracking of progressing human DNA polymerase δ holoenzymes reveals distributions of DNA lesion bypass activities Rachel L Dannenberg, Joseph A Cardina, Kara G Pytko, Mark Hedglin Nucleic Acids Research, Volume 50, Issue 17, 23 September 2022, Pages 9893–9908,
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Changes in the architecture and abundance of replication intermediates delineate the chronology of DNA damage tolerance pathways at UV-stalled replication forks in human cells Yann Benureau, Caroline Pouvelle, Pauline Dupaigne, Sonia Baconnais, Eliana Moreira Tavares, Gerard Mazón, Emmanuelle Despras, Eric Le Cam, Patricia L Kannouche Nucleic Acids Research, Volume 50, Issue 17, 23 September 2022, Pages 9909–9929,
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3D chromatin connectivity underlies replication origin efficiency in mouse embryonic stem cells Karolina Jodkowska, Vera Pancaldi, Maria Rigau, Ricardo Almeida, José M Fernández-Justel, Osvaldo Graña-Castro, Sara Rodríguez-Acebes, Miriam Rubio-Camarillo, Enrique Carrillo-de Santa Pau, David Pisano Fátima Al-Shahrour, Alfonso Valencia, María Gómez, Juan Méndez Nucleic Acids Research, Volume 50, Issue 21, 28 November 2022, Pages 12149–12165,
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