Welcome to the Interactive Section of the site. Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here.

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Publication Alert

Structure of a DNA Polymerase {alpha}-Primase Domain That Docks on the SV40 Helicase and Activates the Viral Primosome

Hao Huang, Brian E. Weiner, Haijiang Zhang, Brian E. Fuller, Yue Gao, Brian M. Wile, Kun Zhao, Diana R. Arnett, Walter J. Chazin, and Ellen Fanning

J. Biol. Chem. 2010 285: 17112-17122.
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Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress

Michael G. Kemp, Zafer Akan, Secil Yilmaz, Mary Grillo, Stephanie L. Smith-Roe, Tae-Hong Kang, Marila Cordeiro-Stone, William K. Kaufmann, Robert T. Abraham, Aziz Sancar, and Keziban Unsal-Kacmaz

J. Biol. Chem. 2010 285: 16562-16571.
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Replication through an abasic DNA lesion: structural basis for adenine selectivity

Samra Obeid, Nina Blatter, Ramon Kranaster, Andreas Schnur, Kay Diederichs, Wolfram Welte and Andreas Marx

The EMBO Journal (2010), 29,1738 – 1747
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Human RECQL5{beta} stimulates flap endonuclease 1

Elzbieta Speina, Lale Dawut, Mohammad Hedayati, ZhengMing Wang, Alfred May, Sybille Schwendener, Pavel Janscak, Deborah L. Croteau, and Vilhelm A. Bohr

Nucl. Acids Res. 2010 38: 2904-2916
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The replisome: A nanomachine or a dynamic dance of protein partners?

Gulfem D. Guler and Ellen Fanning

Cancer Cell Volume 9, Issue 9 Pages 1678 – 1683
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Cdc6/Orc1 from Pyrococcus furiosus may act as the origin recognition protein and Mcm helicase recruiter

Masaki Akita, Akinori Adachi, Kie Takemura, Takeshi Yamagami, Fujihiko Matsunaga, Yoshizumi Ishin

Genes to Cells Volume 15 Issue 5, Pages 537 – 552
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GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication

Alessia Balestrini, Claudia Cosentino, Alessia Errico, Elizabeth Garner & Vincenzo Costanzo

Nature Cell Biology 12, 484 - 491 (2010) 

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Centrosomal Localization of Cyclin E-Cdk2 Is Required for Initiation of DNA Synthesis

Rebecca L. Ferguson,James L. Maller

Current Biology, Volume 20, Issue 9, 856-860, 16 April 2010
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Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast

Jiafeng Wang, Rentian Wu, Yongjun Lu and Chun Liang

Biochemical and Biophysical Research Communications Volume 395, Issue 3, 7 May 2010, Pages 336-341
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Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins

JunGoo Jee, Takeshi Mizuno, Katsuhiko Kamada, Hidehito Tochio, Yasumasa Chiba, Ken-ichiro Yanagi, Gentaro Yasuda, Hidekazu Hiroaki, Fumio Hanaoka and Masahiro Shirakawa

The Journal of Biological Chemistry, 285, 15931-15940.
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CRL4Cdt2 E3 Ubiquitin Ligase Monoubiquitinates PCNA to Promote Translesion DNA Synthesis

Kenta Terai, Tarek Abbas, Amir A. Jazaeri, and Anindya Dutta

Molecular Cell, Volume 37, Issue 1, 143-149
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The p12 Subunit of Human Polymerase δ Modulates the Rate and Fidelity of DNA Synthesis

Xiao Meng, Yajing Zhou, Ernest Y. C. Lee, Marietta Y. W. T. Lee and David N. Frick

Biochemistry, 2010, 49 (17), pp 3545–3554
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What Influences DNA Replication Rate in Budding Yeast?

Thomas W. Spiesser, Christian Diener, Matteo Barberis, Edda Klipp

PLoS ONE 5(4): e10203.
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