Welcome to the Interactive Section of the site. Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here.

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Deep-sea vent phage DNA polymerase specifically initiates DNA synthesis in the absence of primers Bin Zhu, Longfei Wang, Hitoshi Mitsunobu, Xueling Lu, Alfredo J. Hernandez, Yukari Yoshida-Takashima, Takuro Nunoura, Stanley Tabor, and Charles C. Richardson PNAS vol. 114 no. 12 E2310–E2318
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Conserved forkhead dimerization motif controls DNA replication timing and spatial organization of chromosomes in S. cerevisiae A. Zachary Ostrow, Reza Kalhor, Yan Gan, Sandra K. Villwock, Christian Linke, Matteo Barberis, Lin Chen, and Oscar M. Aparicio PNAS 114 no. 12 E2411–E2419,
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Direct Visualization of RNA-DNA Primer Removal from Okazaki Fragments Provides Support for Flap Cleavage and Exonucleolytic Pathways in Eukaryotic Cells Bochao Liu, Jiazhi Hu, Jingna Wang and Daochun Kong The Journal of Biological Chemistry 292, 4777-4788.
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Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase Seiji Matsumoto, Yutaka Kanoh, Michie Shimmoto, Motoshi Hayano, Kyosuke Ueda, Rino Fukatsu, Naoko Kakusho and Hisao Masai Mol. Cell. Biol. April 2017 vol. 37 no. 7 e00355-16
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CRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination James M. Dewar, Emily Low, Matthias Mann, Markus Räschle and Johannes C. Walter Genes & Dev. 2017. 31: 275-290
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The Human RecQ4 Helicase Contains a Functional RecQ C-terminal Region (RQC) That Is Essential for Activity Aditya Mojumdar, Matteo De March, Francesca Marino, and Silvia Onesti J. Biol. Chem. 2017; 292:4176-4184
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Ribosomal Protein S3 Negatively Regulates Unwinding Activity of RecQ-like Helicase 4 through Their Physical Interaction Ajay Vitthal Patil and Tao-Shih Hsieh J. Biol. Chem. 2017; 292:4313-4325 F
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Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation Shin‐ichiro Hiraga, Tony Ly, Javier Garzón, Zuzana Hořejší, Yoshi‐nobu Ohkubo, Akinori Endo, Chikashi Obuse, Simon J Boulton, Angus I Lamond, Anne D Donaldson EMBO Reports (2017) 18: 403–419
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Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization Yating Wang Abid Khan Anna B. Marks Owen K. Smith Sumanprava Giri Yo-Chuen Lin Rachel Creager David M. MacAlpine Kannanganattu V. Prasanth Mirit I. Aladjem Supriya G. Prasanth Nucleic Acids Res (2017) 45 (5): 2490-2502.
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Revealing the role of the product metal in DNA polymerase β catalysis Lalith Perera Bret D. Freudenthal William A. Beard Lee G. Pedersen Samuel H. Wilson Nucleic Acids Res (2017) 45 (5): 2736-2745.
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DNA Replication: How Does a Sliding Clamp Slide? Nina Y. Yao, Mike O’Donnell Current biol Volume 27, Issue 5, pR174–R176, 6 March 2017
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Unearthing worm replication origins Takayo Sasaki & David M Gilbert Nature Structural & Molecular Biology 24, 195–196 (2017)
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The gastrula transition reorganizes replication-origin selection in Caenorhabditis elegans Marta Rodríguez-Martínez, Natalia Pinzón, Charles Ghommidh, Emmanuelle Beyne, Hervé Seitz, Christelle Cayrou & Marcel Méchali Nature Structural & Molecular Biology 24 290–299 (2017)
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Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer Yuanliang Zhai, Erchao Cheng, Hao Wu, Ningning Li, Philip Yuk Kwong Yung, Ning Gao & Bik-Kwoon Tye Nature Structural & Molecular Biology 24 300-308
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Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing Simina Ticau, Larry J Friedman, Kanokwan Champasa, Ivan R Corrêa Jr, Jeff Gelles & Stephen P Bell Nature Structural & Molecular Biology 24 309–315 (2017)
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Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1 Zuanning Yuan, Alberto Riera, Lin Bai, Jingchuan Sun, Saikat Nandi, Christos Spanos, Zhuo Angel Chen, Marta Barbon, Juri Rappsilber, Bruce Stillman, Christian Speck & Huilin Li Nature Structural & Molecular Biology 24 316–324 (2017)
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Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1 Hai Dang Nguyen, Tribhuwan Yadav, Sumanprava Giri, Borja Saez, Timothy A. Graubert, Lee Zou Molecular cell Volume 65, Issue 5, p832–847.e4, 2 March 2017
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