Welcome to the Interactive Section of the site. Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here.

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Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability Jordi Querol-Audía, Chunli Yan, Xiaojun Xu, Susan E. Tsutakawa, Miaw-Sheue Tsai, John A. Tainer, Priscilla K. Cooper, Eva Nogalesa, and Ivaylo Ivanov PNAS May 29, 2012 vol. 109 no. 22 8528-8533
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Cdc6 Protein Obstructs Apoptosome Assembly and Consequent Cell Death by Forming Stable Complexes with Activated Apaf-1 Molecules Shinichiro Niimi, Shiho Arakawa-Takeuchi, Baasanjav Uranbileg, Jun-ha Park, Shigeki Jinno, and Hiroto Okayama J. Biol. Chem. 2012 287: 18573-18583.
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Two Different Replication Factor C Proteins, Ctf18 and RFC1, Separately Control PCNA-CRL4Cdt2-Mediated Cdt1 Proteolysis during S Phase and following UV Irradiation Yasushi Shiomi, Akiyo Hayashi, Takashi Ishii, Kaori Shinmyozu, Jun-ichi Nakayama, Kaoru Sugasawa, and Hideo Nishitani Mol. Cell. Biol. June 2012 32:2279-2288;
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Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen Israel Salguero, Estrella Guarino, Marianne E.A. Shepherd, Tom D. Deegan, Courtney G. Havens, Stuart A. MacNeill, Johannes C. Walter, Stephen E. Kearsey Current Biology, Volume 22, Issue 8, 720-726
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Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends Nikesh Patel, John M. Atack, L. David Finger, Jack C. Exell, Peter Thompson, Susan Tsutakawa, John A. Tainer, David M. Williams, and Jane A.Grasby Nucl. Acids Res. 2012 40: 4507-4519
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Flexible tethering of primase and DNA Pol {alpha} in the eukaryotic primosome Rafael Nunez-Ramirez, Sebastian Klinge, Ludovic Sauguet, Roberto Melero, Maria A. Recuero-Checa, Mairi Kilkenny, Rajika L. Perera, Begona Garcia-Alvarez, Richard J. Hall, Eva Nogales, Luca Pellegrini, and Oscar Llorca Nucl. Acids Res. 2012 40: 4726
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Characterization of DNA Primase Complex Isolated from the Archaeon, Thermococcus kodakaraensis Wiebke Chemnitz Galal, Miao Pan, Zvi Kelman, and Jerard Hurwitz J. Biol. Chem. 2012 287: 16209-16219.
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Effects of Friedreich's ataxia GAA repeats on DNA replication in mammaliancells Gurangad S. Chandok, Mayank P. Patel, Sergei M. Mirkin, and Maria M. Krasilnikova Nucl. Acids Res. 2012 40: 3964-3974 Open Access
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Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation Frederick van Deursen, Sugopa Sengupta, Giacomo De Piccoli, Alberto Sanchez-Diaz and Karim Labib The EMBO Journal (2012), 31,2195 – 2206
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Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components Mai Kanke, Yukako Kodama, Tatsuro S Takahashi, Takuro Nakagawa and Hisao Masukata The EMBO Journal (2012), 31,2182 – 2194
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Depletion of Cellular Pre-Replication Complex Factors Results in Increased Human Cytomegalovirus DNA Replication Tamara Evans Braun, Emma Poole, John Sinclair PLoS ONE 7(5): e36057
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Genome-wide identification and characterization of replication origins by deep sequencing Jia Xu, Yoshimi Yanagisawa, Alexander M Tsankov, Christopher Hart, Keita Aoki, Naveen Kommajosyula, Kathleen E Steinmann, James Bochicchio, Carsten Russ, Aviv Regev, Oliver J Rando, Chad Nusbaum, Hironori Niki, Patrice Milos, Zhiping Weng and Nicholas Rhind Genome Biology 2012, 13:R27
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Cell Cycle-Dependent Mobility of Cdc45 Determined in vivo by Fluorescence Correlation Spectroscopy Ronan Broderick, Sivaramakrishnan Ramadurai, Katalin Tóth, Denisio M. Togashi, Alan G. Ryder, Jörg Langowsk3, Heinz Peter Nasheuer PLoS ONE 7(4): e35537
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Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts Benedicte Recolin, Siem Van Der Laan, and Domenico Maiorano Nucl. Acids Res. 2012 40: 3431-3442
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Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication Chandanamali Punchihewa, Akira Inoue, Asami Hishiki, Yoshihiro Fujikawa, Michele Connelly, Benjamin Evison, Youming Shao, Richard Heath, Isao Kuraoka, Patrick Rodrigues, Hiroshi Hashimoto, Masanobu Kawanishi, Mamoru Sato, Takashi Yagi, and Naoaki Fujii J. Biol. Chem. 2012 287: 14289-14300.
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The Nucleosome Binding Protein HMGN1 Interacts with PCNA and Facilitates Its Binding to Chromatin Yuri V. Postnikov, Toshihiro Kurahashi, Ming Zhou, and Michael Bustin Mol. Cell. Biol. May 2012 32:1844-1854
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