Welcome to the Interactive Section of the site. Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here.

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Site-specific MCM sumoylation prevents genome rearrangements by controlling origin-bound MCM Yun Quan, Qian-yi Zhang, Ann L. Zhou, Yuhao Wang, Jiaxi Cai, Yong-qi Gao, Huilin Zhou PLoS Genet 18(6): e1010275.
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Telomere‐to‐telomere human DNA replication timing profiles Dashiell J. Massey & Amnon Koren Sci rep (2022) 12:9560
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Genome-wide mapping of individual replication fork velocities using nanopore sequencing Bertrand Theulot, Laurent Lacroix, Jean-Michel Arbona, Gael A. Millot, Etienne Jean, Corinne Cruaud, Jade Pellet, Florence Proux, Magali Hennion, Stefan Engelen, Arnaud Lemainque, Benjamin Audit, Olivier Hyrien & Benoît Le Tallec NATURE COMMUNICATIONS | (2022)13:3295
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Cohesin-mediated loop anchors confine the locations of human replication origins Daniel J. Emerson, Peiyao A. Zhao, Ashley L. Cook, R. Jordan Barnett,Kyle N. Klein, Dalila Saulebekova, Chunmin Ge, Linda Zhou, Zoltan Simandi, Miriam K. Minsk, Katelyn R. Titus, Weitao Wang, Wanfeng Gong, Di Zhang, Liyan Yang, Sergey V. Venev, Johan H. Gibcus, Hongbo Yang, Takayo Sasaki, Masato T. Kanemaki, Feng Yue, Job Dekker, Chun-Long Chen, David M. Gilbert & Jennifer E. Phillips-Cremins Nature | Vol606 | 23June2022
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Orc6 is a component of the replication fork and enables efficient mismatch repair Yo-Chuen Lin, Dazhen Liu, Arindam Chakraborty, Lyudmila Y. Kadyrova, You Jin Song, Qinyu Hao, Jaba Mitra, Rosaline Y. C. Hsu, Mariam K. Arif, Sneha Adusumilli, Ting-Wei Liao, Taekjip Ha, Farid A. Kadyrov, Kannanganattu V. Prasanth, and Supriya G. Prasanth PNAS May 27, 2022 119 (22) e2121406119
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HIRA-dependent boundaries between H3 variants shape early replication in mammals Alberto Gatto, Audrey Forest, Jean-Pierre Quivy and Geneviève Almouzni mol cell VOLUME 82, ISSUE 10, P1909-1923.E5,
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Mechanism of replication origin melting nucleated by CMG helicase assembly Jacob S. Lewis, Marta H. Gross, Joana Sousa, Sarah S. Henrikus, Julia F. Greiwe, Andrea Nans, John F. X. Diffley & Alessandro Costa Nature volume 606, pages 1007–1014 (2022)
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DNA Replication proteins in primary microcephaly syndromes Melanie Tingler, Melanie Philipp, Martin D. Burkhalter Biology of the Cell Volume114, Issue June 2022 Pages 143-159
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Insight into RNA–DNA primer length counting by human primosome Andrey G Baranovskiy, Alisa E Lisova, Lucia M Morstadt, Nigar D Babayeva, Tahir H Tahirov Nucleic Acids Research, Volume 50, Issue 11, 24 June 2022, Pages 6264–6270,
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Structures of the human CST-Polα–primase complex bound to telomere templates Qixiang He, Xiuhua Lin, Bianca L. Chavez, Sourav Agrawal, Benjamin L. Lusk & Ci Ji Lim Nature volume 608, pages 826–832 (2022)
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Reconstitution of a telomeric replicon organized by CST Arthur J. Zaug, Karen J. Goodrich, Jessica J. Song, Ashley E. Sullivan & Thomas R. Cech Nature volume 608, pages 819–825 (2022)
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Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity Xiaoxiao Ma, Nadeem Riaz, Robert M. Samstein, Mark Lee, Vladimir Makarov, Cristina Valero, Diego Chowell, Fengshen Kuo, Douglas Hoen, Conall W. R. Fitzgerald, Hui Jiang, Jonathan Alektiar, Tyler J. Alban, Ivan Juric, Prerana Bangalore Parthasarathy, Yu Zhao, Erich Y. Sabio, Richa Verma, Raghvendra M. Srivastava, Lynda Vuong, Wei Yang, Xiao Zhang, Jingming Wang, Lawrence K. Chu, Stephen L. Wang, Daniel W. Kelly, Xin Pei, Jiapeng Chen, Rona Yaeger, Dmitriy Zamarin, Ahmet Zehir, Mithat Gönen, Luc G. T. Morris & Timothy A. Chan Nature Genetics volume 54, pages 996–1012 (2022)
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Mutations in DNA polymerase δ subunit 1 co-segregate with CMD2-type resistance to Cassava Mosaic Geminiviruses Yi-Wen Lim, Ben N. Mansfeld, Pascal Schläpfer, Kerrigan B. Gilbert, Narayanan N. Narayanan, Weihong Qi, Qi Wang, Zhenhui Zhong, Adam Boyher, Jackson Gehan, Getu Beyene, Zuh-Jyh Daniel Lin, Williams Esuma, Suhua Feng, Christelle Chanez, Nadine Eggenberger, Gerald Adiga, Titus Alicai, Steven E. Jacobsen, Nigel J. Taylor, Wilhelm Gruissem & Rebecca S. Bart Nature Communications volume 13, Article number: 3933 (2022)
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Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST Conner L. Olson, Alexandra T. Barbour & Deborah S. Wuttke Nature Structural & Molecular Biology volume 29, pages 730–733 (2022)
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Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels Stephanie R Barbari, Annette K Beach, Joel G Markgren, Vimal Parkash, Elizabeth A Moore, Erik Johansson, Polina V Shcherbakova Nucleic Acids Research, Volume 50, Issue 14, 12 August 2022, Pages 8023–8040,
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Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state Sarah W. Cai, John C. Zinder, Vladimir Svetlov, Martin W. Bush, Evgeny Nudler, Thomas Walz & Titia de Lange Nature Structural & Molecular Biology volume 29, pages 813–819 (2022)
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Nucleosome-directed replication origin licensing independent of a consensus DNA sequence Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell & Shixin Liu Nature Communications volume 13, Article number: 4947 (2022)
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Yeast ORC sumoylation status fine-tunes origin licensing Gemma Regan-Mochrie, Timothy Hoggard, Nikhil Bhagwat, Gerard Lynch, Neil Hunter, Dirk Remus, Catherine A. Fox and Xiaolan Zhao Genes & Dev. 2022. 36: 807-821
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Adaptive exchange sustains cullin–RING ubiquitin ligase networks and proper licensing of DNA replication Yaru Zhang, Marco Jost, Ryan A. Pak, Daniel Lu, Jing Li, Brett Lomenick, Spiros D. Garbis, Chi-Ming Li, Jonathan S. Weissman, James Russell Lipford, and Raymond J. Deshaies PNAS 119 (36) e2205608119
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The DNA replication protein Orc1 from the yeast Torulaspora delbrueckii is required for heterochromatin formation but not as a silencer-binding protein Haniam Maria, Laura N Rusche Genetics, Volume 222, Issue 1, September 2022, iyac110,
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Keeping the strands together: Rad53 regulation of fork symmetry promotes replication stability Zohreh Kianfard, Sarah A. Sabatinos Volume44, Issue9 September 2022 2200141
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Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context Toshihiro Matsukawa, Mianmian Yin, Timour Baslan, Yang Jo Chung, Dengchao Cao, Ryan Bertoli, Yuelin J. Zhu, Robert L. Walker, Amy Freeland, Erik Knudsen, Scott W. Lowe, Paul S. Meltzer, Peter D. Aplan Faseb J September 2022 e22430
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