Welcome to the Interactive Section of the site. Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here.

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A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes Michael Jenkyn-Bedford, Morgan L. Jones, Yasemin Baris, Karim P. M. Labib, Giuseppe Cannone, Joseph T. P. Yeeles & Tom D. Deegan Nature (2021)
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Unwinding of a DNA replication fork by a hexameric viral helicase Abid Javed, Balazs Major, Jonathan A. Stead, Cyril M. Sanders & Elena V. Orlova Nature Communications volume 12, Article number: 5535 (2021)
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Polo-like kinase 1 (Plk1) regulates DNA replication origin firing and interacts with Rif1 in Xenopus Diletta Ciardo, Olivier Haccard, Hemalatha Narassimprakash, David Cornu, Ida Chiara Guerrera, Arach Goldar, Kathrin Marheineke Nucleic Acids Research, Volume 49, Issue 17, 27 September 2021, Pages 9851–9869,
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Disruption of origin chromatin structure by helicase activation in the absence of DNA replication Rachel A. Hoffman, Heather K. MacAlpine and David M. MacAlpine Genes & Dev. 2021. 35: 1339-1355
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SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition Jian Ma, Qing Shi, Gaofeng Cui, Haoyue Sheng, Maria Victoria Botuyan, Yingke Zhou, Yuqian Yan, Yundong He, Liguo Wang, Yuzhuo Wang, Georges Mer, Dingwei Ye, Chenji Wang & Haojie Huang Nature Communications volume 12, Article number: 5779 (2021)
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Increased somatic mutation burdens in normal human cells due to defective DNA polymerases Philip S. Robinson, Tim H. H. Coorens, Claire Palles, Emily Mitchell, Federico Abascal, Sigurgeir Olafsson, Bernard C. H. Lee, Andrew R. J. Lawson, Henry Lee-Six, Luiza Moore, Mathijs A. Sanders, James Hewinson, Lynn Martin, Claudia M. A. Pinna, Sara Galavotti, Raheleh Rahbari, Peter J. Campbell, Iñigo Martincorena, Ian Tomlinson & Michael R. Stratton Nature Genetics volume 53, pages 1434–1442 (2021)
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POLE, POLD1, and NTHL1: the last but not the least hereditary cancer-predisposing genes Luigi Magrin, Daniele Fanale, Chiara Brando, Alessia Fiorino, Lidia Rita Corsini, Roberta Sciacchitano, Clarissa Filorizzo, Alessandra Dimino, Antonio Russo & Viviana Bazan Oncogene volume 40, pages 5893–5901 (2021)
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The Fkh1 Forkhead associated domain promotes ORC binding to a subset of DNA replication origins in budding yeast Timothy Hoggard, Allison J Hollatz, Rachel E Cherney, Melissa R Seman, Catherine A Fox Nucleic Acids Research, Volume 49, Issue 18, 11 October 2021, Pages 10207–10220,
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Fission yeast Stn1 maintains stability of repetitive DNA at subtelomere and ribosomal DNA regions Io Yamamoto, Hidenori Nakaoka, Masahiro Takikawa, Sanki Tashiro, Junko Kanoh, Tomoichiro Miyoshi, Fuyuki Ishikawa Nucleic Acids Research, Volume 49, Issue 18, 11 October 2021, Pages 10465–10476,
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The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase Kimberlie A Wittig, Courtney G Sansam, Tyler D Noble, Duane Goins, Christopher L Sansam Nucleic Acids Research, Volume 49, Issue 18, 11 October 2021, Pages 10507–10523,
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Frequency and patterns of ribonucleotide incorporation around autonomously replicating sequences in yeast reveal the division of labor of replicative DNA polymerases Penghao Xu, Francesca Storici Nucleic Acids Research, Volume 49, Issue 18, 11 October 2021, Pages 10542–10557,
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Anatomy and evolution of a DNA replication origin Yutaka Yamamoto, Eric A. Gustafson, Michael S. Foulk, Heidi S. Smith & Susan A. Gerbi Chromosoma volume 130, pages 199–214 (2021)
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DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity Qian Du, Grady C. Smith, Phuc Loi Luu, James M. Ferguson, Nicola J. Armstrong, C. Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena ZotenkoCathryn M. Gould,Michael Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik Kaczorowski, Chia-Ling Chan, Kirston Barton, Ira W. Deveson, Martin A. Smith, Joseph E. Powell, Ksenia Skvortsova, Clare Stirzaker, Joanna Achinger-Kawecka, Susan J. Clark Cell reports ARTICLE| VOLUME 36, ISSUE 12, 109722, SEPTEMBER 21, 2021
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